Anti-CD105/ENG antibody [SAA0041] {FITC} (STJA0028274)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Human monoclonal Endoglin antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0041 |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 05 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months Protect from light Do not freeze |
Target Information
| Gene Symbol | ENG |
| Gene ID | 2022 |
| Uniprot ID | EGLN_HUMAN |
Additional Info
| Function | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. |
| Protein Name | EndoglinCd Antigen Cd105 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Endoglin antibodyAnti-Cd Antigen Cd105 antibodyAnti-ENG antibodyAnti-END antibody |
Information sourced from Uniprot.org