| Host: | Rabbit |
| Applications: | WB/IHC/IF/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-Cyclin A2 (11-210) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S4MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200IP 1:100-1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNA2 |
| Gene ID: | 890 |
| Uniprot ID: | CCNA2_HUMAN |
| Immunogen Region: | 11-210 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 11-210 of human Cyclin A2 (P20248). |
| Immunogen Sequence: | TREAGSALLALQQTALQEDQ ENINPEKAAPVQQPRTRAAL AVLKSGNPRGLAQQQRPKTR RVAPLKDLPVNDEHVTVPPW KANSKQPAFTIHVDEAEKEA QKKPAESQKIEREDALAFNS AISLPGPRKPLVPLDYPMDG SFESPHTMDMSIILEDEKPV SVNEVPDYHEDIHTYLREME VKCKPKVGYMKKQPDITNSM |
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. |
| Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
| Protein Name | Cyclin-A2Cyclin-ACyclin A |
| Database Links | Reactome: R-HSA-1362300Reactome: R-HSA-1538133Reactome: R-HSA-170145Reactome: R-HSA-171319Reactome: R-HSA-174184Reactome: R-HSA-176408Reactome: R-HSA-187577Reactome: R-HSA-2559582Reactome: R-HSA-2559586Reactome: R-HSA-5689880Reactome: R-HSA-5693607Reactome: R-HSA-6804116Reactome: R-HSA-6804756Reactome: R-HSA-6804757Reactome: R-HSA-68911Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69273Reactome: R-HSA-69563Reactome: R-HSA-69656 |
| Cellular Localisation | NucleusCytoplasmExclusively Nuclear During InterphaseDetected In The Nucleus And The Cytoplasm At ProphaseCytoplasmic When Associated With Scaper |
| Alternative Antibody Names | Anti-Cyclin-A2 antibodyAnti-Cyclin-A antibodyAnti-Cyclin A antibodyAnti-CCNA2 antibodyAnti-CCN1 antibodyAnti-CCNA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
