| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Coiled-coil domain-containing protein 115 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VMA22 |
| Gene ID: | 84317 |
| Uniprot ID: | VMA22_HUMAN |
| Specificity: | This antibody detects endogenous levels of CCDC115 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human CCDC115 |
| Function | Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis. |
| Protein Name | Vacuolar Atpase Assembly Protein Vma22Coiled-Coil Domain-Containing Protein 115 |
| Database Links | Reactome: R-HSA-8980692 |
| Cellular Localisation | EndosomeLysosomeEndoplasmic Reticulum-Golgi Intermediate CompartmentCytoplasmic VesicleCopi-Coated VesicleEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Vacuolar Atpase Assembly Protein Vma22 antibodyAnti-Coiled-Coil Domain-Containing Protein 115 antibodyAnti-VMA22 antibodyAnti-CCDC115 antibody |
Information sourced from Uniprot.org
