| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-CC2D1A (750-951) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CC2D1A |
| Gene ID: |
54862 |
| Uniprot ID: |
C2D1A_HUMAN |
| Immunogen Region: |
750-951 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 750-951 of human CC2D1A (Q6P1N0). |
| Immunogen Sequence: |
VLGTAQLKLDALEIACEVRE ILEVLDGRRPTGGRLEVMVR IREPLTAQQLETTTERWLVI DPVPAAVPTQVAGPKGKAPP VPAPARESGNRSARPLHSLS VLAFDQERLERKILALRQAR RPVPPEVAQQYQDIMQRSQW QRAQLEQGGVGIRREYAAQL ERQLQFYTEAARRLGNDGSR DAAKEALYRRNLVESELQRL RR |
| Post Translational Modifications | Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21. |
| Function | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. |
| Protein Name | Coiled-Coil And C2 Domain-Containing Protein 1aAkt Kinase-Interacting Protein 1Five Prime Repressor Element Under Dual Repression-Binding Protein 1Fre Under Dual Repression-Binding Protein 1Freud-1Putative Nf-Kappa-B-Activating Protein 023n |
| Cellular Localisation | CytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-Coiled-Coil And C2 Domain-Containing Protein 1a antibodyAnti-Akt Kinase-Interacting Protein 1 antibodyAnti-Five Prime Repressor Element Under Dual Repression-Binding Protein 1 antibodyAnti-Fre Under Dual Repression-Binding Protein 1 antibodyAnti-Freud-1 antibodyAnti-Putative Nf-Kappa-B-Activating Protein 023n antibodyAnti-CC2D1A antibodyAnti-AKI1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
