Anti-CBX8 antibody (80-280) (STJ27978)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CBX8 (80-280) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBX8 |
| Gene ID | 57332 |
| Uniprot ID | CBX8_HUMAN |
| Immunogen Region | 80-280 |
| Immunogen Sequence | LLKAQAKAKAKTYEFRSDSA RGIRIPYPGRSPQDLASTSR AREGLRNMGLSPPASSTSTS STCRAEAPRDRDRDRDRDRE RDRERERERERERERERERE RGTSRVDDKPSSPGDSSKKR GPKPRKELPDPSQRPLGEPS AGLGEYLKGRKLDDTPSGAG KFPAGHSVIQLARRQDSDLV QCGVTSPSSAEATGKLAVDT F |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human CBX8 (NP_065700.1). |
Additional Info
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Protein Name | Chromobox Protein Homolog 8Polycomb 3 HomologPc3Hpc3Rectachrome 1 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 8 antibodyAnti-Polycomb 3 Homolog antibodyAnti-Pc3 antibodyAnti-Hpc3 antibodyAnti-Rectachrome 1 antibodyAnti-CBX8 antibodyAnti-PC3 antibodyAnti-RC1 antibody |
Information sourced from Uniprot.org