Anti-CBS antibody (1-551) (STJ22918)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CBS (1-551) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBS |
| Gene ID | 102724560/875 |
| Uniprot ID | CBS_HUMAN |
| Immunogen Region | 1-551 |
| Immunogen Sequence | MPSETPQAEVGPTGCPHRSG PHSAKGSLEKGSPEDKEAKE PLWIRPDAPSRCTWQLGRPA SESPHHHTAPAKSPKILPDI LKKIGDTPMVRINKIGKKFG LKCELLAKCEFFNAGGSVKD RISLRMIEDAERDGTLKPGD TIIEPTSGNTGIGLALAAAV RGYRCIIVMPEKMSSEKVDV LRALGAEIVRTPTNARFDSP ESHVGVAWRLKNEIPNSHIL DQYRNASNPLAHYDTTADE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human CBS (NP_000062.1). |
Additional Info
| Tissue Specificity | In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney. |
| Function | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. |
| Protein Name | Cystathionine Beta-SynthaseBeta-ThionaseSerine Sulfhydrase |
| Database Links | Reactome: R-HSA-1614603Reactome: R-HSA-2408508 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cystathionine Beta-Synthase antibodyAnti-Beta-Thionase antibodyAnti-Serine Sulfhydrase antibodyAnti-CBS antibody |
Information sourced from Uniprot.org