• Immunofluorescence analysis of human liver cancer using CBS Rabbit polyclonal antibody (STJ22918) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of rat liver using CBS Rabbit polyclonal antibody (STJ22918) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Western blot analysis of extracts of various cell lines, using CBS Polyclonal Antibody (STJ22918) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-CBS antibody (1-551) (STJ22918)

SKU:
STJ22918

£112.50 - £522.50
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CBS (1-551) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CBS
Gene ID: 102724560/875
Uniprot ID: CBS_HUMAN
Immunogen Region: 1-551
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-551 of human CBS (NP_000062.1).
Immunogen Sequence: MPSETPQAEVGPTGCPHRSG PHSAKGSLEKGSPEDKEAKE PLWIRPDAPSRCTWQLGRPA SESPHHHTAPAKSPKILPDI LKKIGDTPMVRINKIGKKFG LKCELLAKCEFFNAGGSVKD RISLRMIEDAERDGTLKPGD TIIEPTSGNTGIGLALAAAV RGYRCIIVMPEKMSSEKVDV LRALGAEIVRTPTNARFDSP ESHVGVAWRLKNEIPNSHIL DQYRNASNPLAHYDTTADE
Tissue Specificity In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
Function Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
Protein Name Cystathionine Beta-Synthase
Beta-Thionase
Serine Sulfhydrase
Database Links Reactome: R-HSA-1614603
Reactome: R-HSA-2408508
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Cystathionine Beta-Synthase antibody
Anti-Beta-Thionase antibody
Anti-Serine Sulfhydrase antibody
Anti-CBS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance