| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CBR3 (118-277) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CBR3 |
| Gene ID: |
874 |
| Uniprot ID: |
CBR3_HUMAN |
| Immunogen Region: |
118-277 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 118-277 of human CBR3 (NP_001227.1). |
| Immunogen Sequence: |
TRNMCNELLPIMKPHGRVVN ISSLQCLRAFENCSEDLQER FHSETLTEGDLVDLMKKFVE DTKNEVHEREGWPNSPYGVS KLGVTVLSRILARRLDEKRK ADRILVNACCPGPVKTDMDG KDSIRTVEEGAETPVYLALL PPDATEPQGQLVHDKVVQNW |
| Tissue Specificity | Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis. |
| Function | Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified. |
| Protein Name | Carbonyl Reductase Nadph 3Nadph-Dependent Carbonyl Reductase 3Quinone Reductase Cbr3Short Chain Dehydrogenase/Reductase Family 21c Member 2 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Carbonyl Reductase Nadph 3 antibodyAnti-Nadph-Dependent Carbonyl Reductase 3 antibodyAnti-Quinone Reductase Cbr3 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 21c Member 2 antibodyAnti-CBR3 antibodyAnti-SDR21C2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of RAW264. 7 cells using [KO Validated] Caspase-3 Rabbit polyclonal antibody (STJ11101178) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/90100/358863/STJ11101178_1__46120.1713123228.jpg?c=1 "Immunofluorescence analysis of RAW264. 7 cells using [KO Validated] Caspase-3 Rabbit polyclonal antibody (STJ11101178) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
