Anti-CBR3 antibody (118-277) (STJ29683)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CBR3 (118-277) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBR3 |
| Gene ID | 874 |
| Uniprot ID | CBR3_HUMAN |
| Immunogen Region | 118-277 |
| Immunogen Sequence | TRNMCNELLPIMKPHGRVVN ISSLQCLRAFENCSEDLQER FHSETLTEGDLVDLMKKFVE DTKNEVHEREGWPNSPYGVS KLGVTVLSRILARRLDEKRK ADRILVNACCPGPVKTDMDG KDSIRTVEEGAETPVYLALL PPDATEPQGQLVHDKVVQNW |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 118-277 of human CBR3 (NP_001227.1). |
Additional Info
| Tissue Specificity | Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis. |
| Function | Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified. |
| Protein Name | Carbonyl Reductase Nadph 3Nadph-Dependent Carbonyl Reductase 3Quinone Reductase Cbr3Short Chain Dehydrogenase/Reductase Family 21c Member 2 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Carbonyl Reductase Nadph 3 antibodyAnti-Nadph-Dependent Carbonyl Reductase 3 antibodyAnti-Quinone Reductase Cbr3 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 21c Member 2 antibodyAnti-CBR3 antibodyAnti-SDR21C2 antibody |
Information sourced from Uniprot.org