Anti-CBLL1 antibody (1-240) (STJ117131)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CBLL1 (1-240) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBLL1 |
| Gene ID | 79872 |
| Uniprot ID | HAKAI_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MDHTDNELQGTNSSGSLGGL DVRRRIPIKLISKQANKAKP APRTQRTINRMPAKAPPGDE EGFDYNEEERYDCKGGELFA NQRRFPGHLFWDFQINILGE KDDTPVHFCDKCGLPIKIYG RMIPCKHVFCYDCAILHEKK GDKMCPGCSDPVQRIEQCTR GSLFMCSIVQGCKRTYLSQR DLQAHINHRHMRAGKPVTRA SLENVHPPIAPPPTEIPERF IMPPDKHHMSHIPPKQHIM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2). |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. |
| Protein Name | E3 Ubiquitin-Protein Ligase HakaiCasitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1C-Cbl-Like Protein 1Ring Finger Protein 188Ring-Type E3 Ubiquitin Transferase Hakai |
| Database Links | Reactome: R-HSA-8876493 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hakai antibodyAnti-Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 antibodyAnti-C-Cbl-Like Protein 1 antibodyAnti-Ring Finger Protein 188 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Hakai antibodyAnti-CBLL1 antibodyAnti-HAKAI antibodyAnti-RNF188 antibody |
Information sourced from Uniprot.org