| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CBLL1 |
| Gene ID: | 79872 |
| Uniprot ID: | HAKAI_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2). |
| Immunogen Sequence: | MDHTDNELQGTNSSGSLGGL DVRRRIPIKLISKQANKAKP APRTQRTINRMPAKAPPGDE EGFDYNEEERYDCKGGELFA NQRRFPGHLFWDFQINILGE KDDTPVHFCDKCGLPIKIYG RMIPCKHVFCYDCAILHEKK GDKMCPGCSDPVQRIEQCTR GSLFMCSIVQGCKRTYLSQR DLQAHINHRHMRAGKPVTRA SLENVHPPIAPPPTEIPERF IMPPDKHHMSHIPPKQHIM |
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hakai Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 C-Cbl-Like Protein 1 Ring Finger Protein 188 Ring-Type E3 Ubiquitin Transferase Hakai |
| Database Links | Reactome: R-HSA-8876493 |
| Cellular Localisation | Nucleus Speckle Nucleus Nucleoplasm Cytoplasm Mainly Nuclear With Some Fraction Located In The Cytoplasm Zc3h13 Is Required To Anchor Component Of The Macom Subcomplex Such As Virma In The Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hakai antibody Anti-Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 antibody Anti-C-Cbl-Like Protein 1 antibody Anti-Ring Finger Protein 188 antibody Anti-Ring-Type E3 Ubiquitin Transferase Hakai antibody Anti-CBLL1 antibody Anti-HAKAI antibody Anti-RNF188 antibody |
Information sourced from Uniprot.org