Anti-cathepsin C/DPP1 antibody (238-252) (STJ72905)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-cathepsin C/DPP1 (238-252) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 24kDa band observed in Human Neutrophils lysates (calculated MW of 51.8kDa according to NP_001805.3). This molecular weight is routinely observed by other sources. Recommended |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CTSC |
| Gene ID | 1075 |
| Uniprot ID | CATC_HUMAN |
| Accession Number | NP_001805.3 |
| Immunogen Region | 238-252 |
| Immunogen Sequence | RNVHGINFVSPVRNQ |
| Specificity | This antibody is expected to recognize isoform a (NP_001805.3) only. |
Additional Info
| Post Translational Modifications | N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes. In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond. |
| Function | Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. |
| Protein Name | Dipeptidyl Peptidase 1Cathepsin CCathepsin JDipeptidyl Peptidase IDpp-IDppiDipeptidyl Transferase Cleaved Into - Dipeptidyl Peptidase 1 Exclusion Domain ChainDipeptidyl Peptidase I Exclusion Domain Chain - Dipeptidyl Peptidase 1 Heavy ChainDipeptidyl Peptidase I Heavy Chain - Dipeptidyl Peptidase 1 Light ChainDipeptidyl Peptidase I Light Chain |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-2132295Reactome: R-HSA-5694530Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Dipeptidyl Peptidase 1 antibodyAnti-Cathepsin C antibodyAnti-Cathepsin J antibodyAnti-Dipeptidyl Peptidase I antibodyAnti-Dpp-I antibodyAnti-Dppi antibodyAnti-Dipeptidyl Transferase Cleaved Into - Dipeptidyl Peptidase 1 Exclusion Domain Chain antibodyAnti-Dipeptidyl Peptidase I Exclusion Domain Chain - Dipeptidyl Peptidase 1 Heavy Chain antibodyAnti-Dipeptidyl Peptidase I Heavy Chain - Dipeptidyl Peptidase 1 Light Chain antibodyAnti-Dipeptidyl Peptidase I Light Chain antibodyAnti-CTSC antibodyAnti-CPPI antibody |
Information sourced from Uniprot.org