| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CASQ2 (20-399) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CASQ2 |
| Gene ID: |
845 |
| Uniprot ID: |
CASQ2_HUMAN |
| Immunogen Region: |
20-399 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2). |
| Immunogen Sequence: |
EEGLNFPTYDGKDRVVSLSE KNFKQVLKKYDLLCLYYHEP VSSDKVTQKQFQLKEIVLEL VAQVLEHKAIGFVMVDAKKE AKLAKKLGFDEEGSLYILKG DRTIEFDGEFAADVLVEFLL DLIEDPVEIISSKLEVQAFE RIEDYIKLIGFFKSEDSEYY KAFEEAAEHFQPYIKFFATF DKGVAKKLSLKMNEVDFYEP FMDEPIAIPNKPYTEEELVE FVKEHQRPTLRRLRPEEMF |
| Post Translational Modifications | Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity. N-glycosylated. |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2.this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. |
| Protein Name | Calsequestrin-2Calsequestrin - Cardiac Muscle Isoform |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum LumenThis Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Cardiac And Slow Skeletal Muscle Cells |
| Alternative Antibody Names | Anti-Calsequestrin-2 antibodyAnti-Calsequestrin - Cardiac Muscle Isoform antibodyAnti-CASQ2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
