Anti-CASQ2 antibody (20-399) (STJ119183)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CASQ2 (20-399) antibody for use in WB, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CASQ2 |
| Gene ID | 845 |
| Uniprot ID | CASQ2_HUMAN |
| Immunogen Region | 20-399 |
| Immunogen Sequence | EEGLNFPTYDGKDRVVSLSE KNFKQVLKKYDLLCLYYHEP VSSDKVTQKQFQLKEIVLEL VAQVLEHKAIGFVMVDAKKE AKLAKKLGFDEEGSLYILKG DRTIEFDGEFAADVLVEFLL DLIEDPVEIISSKLEVQAFE RIEDYIKLIGFFKSEDSEYY KAFEEAAEHFQPYIKFFATF DKGVAKKLSLKMNEVDFYEP FMDEPIAIPNKPYTEEELVE FVKEHQRPTLRRLRPEEMF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2). |
Additional Info
| Post Translational Modifications | Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity. N-glycosylated. |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2.this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. |
| Protein Name | Calsequestrin-2Calsequestrin - Cardiac Muscle Isoform |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum LumenThis Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Cardiac And Slow Skeletal Muscle Cells |
| Alternative Antibody Names | Anti-Calsequestrin-2 antibodyAnti-Calsequestrin - Cardiac Muscle Isoform antibodyAnti-CASQ2 antibody |
Information sourced from Uniprot.org