Anti-Caspr1 antibody (700-800) [S2MR] (STJ11103532)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Caspr1 (700-800) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNTNAP1 |
| Gene ID | 8506 |
| Uniprot ID | CNTP1_HUMAN |
| Immunogen Region | 700-800 |
| Immunogen Sequence | EQHFYWGGSQPGIQRCACGL DRSCVDPALYCNCDADQPQW RTDKGLLTFVDHLPVTQVVI GDTNRSTSEAQFFLRPLRCY GDRNSWNTISFHTGAALRFP P |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human Caspr11 (P78357). |
Additional Info
| Tissue Specificity | Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis. |
| Function | Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. |
| Protein Name | Contactin-Associated Protein 1CasprCaspr1Neurexin IvNeurexin-4P190 |
| Database Links | Reactome: R-HSA-447043 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell JunctionParanodal Septate Junction |
| Alternative Antibody Names | Anti-Contactin-Associated Protein 1 antibodyAnti-Caspr antibodyAnti-Caspr1 antibodyAnti-Neurexin Iv antibodyAnti-Neurexin-4 antibodyAnti-P190 antibodyAnti-CNTNAP1 antibodyAnti-CASPR antibodyAnti-NRXN4 antibody |
Information sourced from Uniprot.org