Anti-CARMIL1 antibody (853-903 aa) (STJ195878)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human LR16A at the amino acid range 853-903
General Information
| Short Description | Rabbit polyclonal anti-F-actin-uncapping protein LRRC16A (853-903 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CARMIL1 |
| Gene ID | 55604 |
| Uniprot ID | CARL1_HUMAN |
| Immunogen | Synthesized peptide derived from the human LR16A at the amino acid range 853-903 |
| Immunogen Region | 853-903 aa |
| Specificity | This antibody detects endogenous levels of LR16A at Human/Mouse |
Additional Info
| Function | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration. |
| Protein Name | F-Actin-Uncapping Protein Lrrc16aCarmil HomologCapping Protein Regulator And Myosin 1 Linker Protein 1Capping Protein - Arp2/3 And Myosin-I Linker Homolog 1Capping Protein - Arp2/3 And Myosin-I Linker Protein 1Leucine-Rich Repeat-Containing Protein 16a |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneCell ProjectionLamellipodiumFound On MacropinosomesColocalized With Heterodimeric Capping Protein (Cp) And F-Actin In Lamellipodia But Not With F-Actin In Stress Fibers |
| Alternative Antibody Names | Anti-F-Actin-Uncapping Protein Lrrc16a antibodyAnti-Carmil Homolog antibodyAnti-Capping Protein Regulator And Myosin 1 Linker Protein 1 antibodyAnti-Capping Protein - Arp2/3 And Myosin-I Linker Homolog 1 antibodyAnti-Capping Protein - Arp2/3 And Myosin-I Linker Protein 1 antibodyAnti-Leucine-Rich Repeat-Containing Protein 16a antibodyAnti-CARMIL1 antibodyAnti-CARMIL antibodyAnti-LRRC16 antibodyAnti-LRRC16A antibody |
Information sourced from Uniprot.org