Anti-CARD16 antibody (50-150) (STJ119051)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CARD16 (50-150) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CARD16 |
| Gene ID | 114769 |
| Uniprot ID | CAR16_HUMAN |
| Immunogen Region | 50-150 |
| Immunogen Sequence | VMDKTRALIDSVIPKGAQAC QICITYICEEDSYLAETLGL SAALQAVQDNPAMPTCSSPE GRIKLCFLEDAQRIWKQKLQ RCHVQNTIIKWSERYTSGSF E |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CARD16 (NP_001017534.1). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. |
| Function | Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. |
| Protein Name | Caspase Recruitment Domain-Containing Protein 16Caspase Recruitment Domain-Only Protein 1Card-Only Protein 1Caspase-1 Inhibitor CopPseudo Interleukin-1 Beta Converting EnzymePseudo-IcePseudo-Il1b-Converting Enzyme |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Caspase Recruitment Domain-Containing Protein 16 antibodyAnti-Caspase Recruitment Domain-Only Protein 1 antibodyAnti-Card-Only Protein 1 antibodyAnti-Caspase-1 Inhibitor Cop antibodyAnti-Pseudo Interleukin-1 Beta Converting Enzyme antibodyAnti-Pseudo-Ice antibodyAnti-Pseudo-Il1b-Converting Enzyme antibodyAnti-CARD16 antibodyAnti-COP antibodyAnti-COP1 antibody |
Information sourced from Uniprot.org