| Tissue Specificity | Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. |
| Function | Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. |
| Protein Name | Caspase Recruitment Domain-Containing Protein 16Caspase Recruitment Domain-Only Protein 1Card-Only Protein 1Caspase-1 Inhibitor CopPseudo Interleukin-1 Beta Converting EnzymePseudo-IcePseudo-Il1b-Converting Enzyme |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Caspase Recruitment Domain-Containing Protein 16 antibodyAnti-Caspase Recruitment Domain-Only Protein 1 antibodyAnti-Card-Only Protein 1 antibodyAnti-Caspase-1 Inhibitor Cop antibodyAnti-Pseudo Interleukin-1 Beta Converting Enzyme antibodyAnti-Pseudo-Ice antibodyAnti-Pseudo-Il1b-Converting Enzyme antibodyAnti-CARD16 antibodyAnti-COP antibodyAnti-COP1 antibody |
Information sourced from Uniprot.org
