Anti-CAPZA1 antibody (1-286) (STJ22887)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CAPZA1 (1-286) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAPZA1 |
| Gene ID | 829 |
| Uniprot ID | CAZA1_HUMAN |
| Immunogen Region | 1-286 |
| Immunogen Sequence | MADFDDRVSDEEKVRIAAKF ITHAPPGEFNEVFNDVRLLL NNDNLLREGAAHAFAQYNMD QFTPVKIEGYEDQVLITEHG DLGNSRFLDPRNKISFKFDH LRKEASDPQPEEADGGLKSW RESCDSALRAYVKDHYSNGF CTVYAKTIDGQQTIIACIES HQFQPKNFWNGRWRSEWKFT ITPPTAQVVGVLKIQVHYYE DGNVQLVSHKDVQDSLTVSN EAQTAKEFIKIIENAENEY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human CAPZA1 (NP_006126.1). |
Additional Info
| Function | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | F-Actin-Capping Protein Subunit Alpha-1Capz Alpha-1 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-3371497Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-879415Reactome: R-HSA-8950505Reactome: R-HSA-9662360Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-F-Actin-Capping Protein Subunit Alpha-1 antibodyAnti-Capz Alpha-1 antibodyAnti-CAPZA1 antibody |
Information sourced from Uniprot.org