| Post Translational Modifications | Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4. |
| Function | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 1Cam-Kk 1Cam-Kinase Kinase 1Camkk 1Cam-Kinase Iv KinaseCalcium/Calmodulin-Dependent Protein Kinase Kinase AlphaCam-Kk AlphaCam-Kinase Kinase AlphaCamkk Alpha |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-442729Reactome: R-HSA-9619229 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 antibodyAnti-Cam-Kk 1 antibodyAnti-Cam-Kinase Kinase 1 antibodyAnti-Camkk 1 antibodyAnti-Cam-Kinase Iv Kinase antibodyAnti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha antibodyAnti-Cam-Kk Alpha antibodyAnti-Cam-Kinase Kinase Alpha antibodyAnti-Camkk Alpha antibodyAnti-CAMKK1 antibodyAnti-CAMKKA antibody |
Information sourced from Uniprot.org
