| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CAMKK1 (399-520) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CAMKK1 |
| Gene ID: |
84254 |
| Uniprot ID: |
KKCC1_HUMAN |
| Immunogen Region: |
399-520 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 399-520 of human CAMKK1 (NP_757344.2). |
| Immunogen Sequence: |
LHRKIKNEPVVFPEEPEISE ELKDLILKMLDKNPETRIGV PDIKLHPWVTKNGEEPLPSE EEHCSVVEVTEEEVKNSVRL IPSWTTVILVKSMLRKRSFG NPFEPQARREERSMSAPGNL LV |
| Post Translational Modifications | Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4. |
| Function | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 1Cam-Kk 1Cam-Kinase Kinase 1Camkk 1Cam-Kinase Iv KinaseCalcium/Calmodulin-Dependent Protein Kinase Kinase AlphaCam-Kk AlphaCam-Kinase Kinase AlphaCamkk Alpha |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-442729Reactome: R-HSA-9619229 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 antibodyAnti-Cam-Kk 1 antibodyAnti-Cam-Kinase Kinase 1 antibodyAnti-Camkk 1 antibodyAnti-Cam-Kinase Iv Kinase antibodyAnti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha antibodyAnti-Cam-Kk Alpha antibodyAnti-Cam-Kinase Kinase Alpha antibodyAnti-Camkk Alpha antibodyAnti-CAMKK1 antibodyAnti-CAMKKA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
