Anti-CAMK1D antibody (1-180) (STJ115396)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CAMK1D (1-180) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAMK1D |
| Gene ID | 57118 |
| Uniprot ID | KCC1D_HUMAN |
| Immunogen Region | 1-180 |
| Immunogen Sequence | MARENGESSSSWKKQAEDIK KIFEFKETLGTGAFSEVVLA EEKATGKLFAVKCIPKKALK GKESSIENEIAVLRKIKHEN IVALEDIYESPNHLYLVMQL VSGGELFDRIVEKGFYTEKD ASTLIRQVLDAVYYLHRMGI VHRDLKPENLLYYSQDEESK IMISDFGLSKMEGKGDVMST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CAMK1D (NP_705718.1). |
Additional Info
| Tissue Specificity | Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. |
| Function | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type 1dCam Kinase I DeltaCam Kinase IdCam-Ki DeltaCamki DeltaCamkidCamki-Like Protein KinaseCklik |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicNuclear Localization Increases Upon Activation By Kcl Treatment In Hippocampal Neurons |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Type 1d antibodyAnti-Cam Kinase I Delta antibodyAnti-Cam Kinase Id antibodyAnti-Cam-Ki Delta antibodyAnti-Camki Delta antibodyAnti-Camkid antibodyAnti-Camki-Like Protein Kinase antibodyAnti-Cklik antibodyAnti-CAMK1D antibodyAnti-CAMKID antibody |
Information sourced from Uniprot.org