| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CALHM2 |
| Gene ID: | 51063 |
| Uniprot ID: | CAHM2_HUMAN |
| Immunogen Region: | 1-323 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human CALHM2 (NP_057000.2). |
| Immunogen Sequence: | MAALIAENFRFLSLFFKSKD VMIFNGLVALGTVGSQELFS VVAFHCPCSPARNYLYGLAA IGVPALVLFIIGIILNNHTW NLVAECQHRRTKNCSAAPTF LLLSSILGRAAVAPVTWSVI SLLRGEAYVCALSEFVDPSS LTAREEHFPSAHATEILARF PCKENPDNLSDFREEVSRRL RYESQLFGWLLIGVVAILVF LTKCLKHYCSPLSYRQEAYW AQYRANEDQLFQRTAEVHS |
| Tissue Specificity | Placenta. |
| Function | Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown. |
| Protein Name | Calcium Homeostasis Modulator Protein 2Protein Fam26b |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium Homeostasis Modulator Protein 2 antibodyAnti-Protein Fam26b antibodyAnti-CALHM2 antibodyAnti-FAM26B antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and ERCC1 knockout (KO) HeLa cells, using [KO Validated] ERCC1 Rabbit polyclonal antibody (STJ11100039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89111/357565/STJ11100039_1__56308.1713121691.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ERCC1 knockout (KO) HeLa cells, using [KO Validated] ERCC1 Rabbit polyclonal antibody (STJ11100039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.")
