Anti-CALHM2 antibody (160-210 aa) (STJ13101000)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 160-210 of human CALHM2 conjugated to blue carrier protein was used as the antigen. The peptide shares 83% identity with rat and mouse sequences.
General Information
| Short Description | Rabbit polyclonal anti-CALHM2 (160-210 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CALHM2 |
| Gene ID | 51063 |
| Uniprot ID | CAHM2_HUMAN |
| Immunogen | A synthetic peptide from aa region 160-210 of human CALHM2 conjugated to blue carrier protein was used as the antigen. The peptide shares 83% identity with rat and mouse sequences. |
| Immunogen Region | 160-210 aa |
| Specificity | Specific for CALHM2. |
Additional Info
| Function | Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown. |
| Protein Name | Calcium Homeostasis Modulator Protein 2Protein Fam26b |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium Homeostasis Modulator Protein 2 antibodyAnti-Protein Fam26b antibodyAnti-CALHM2 antibodyAnti-FAM26B antibody |
Information sourced from Uniprot.org