Anti-CACNB1 antibody (429-598) (STJ29963)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CACNB1 (429-598) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNB1 |
| Gene ID | 782 |
| Uniprot ID | CACB1_HUMAN |
| Immunogen Region | 429-598 |
| Immunogen Sequence | ATAALAASPAPVSNLQGPYL ASGDQPLERATGEHASMHEY PGELGQPPGLYPSSHPPGRA GTLRALSRQDTFDADTPGSR NSAYTELGDSCVDMETDPSE GPGLGDPAGGGTPPARQGSW EDEEEDYEEELTDNRNRGRN KARYCAEGGGPVLGRNKNEL EGWGRGVYIR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 429-598 of human CACNB1 (NP_000714.3). |
Additional Info
| Tissue Specificity | Detected in heart ventricle (at protein level). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. |
| Function | Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Beta-1Cab1Calcium Channel Voltage-Dependent Subunit Beta 1 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-419037Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-9856532 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-1 antibodyAnti-Cab1 antibodyAnti-Calcium Channel Voltage-Dependent Subunit Beta 1 antibodyAnti-CACNB1 antibodyAnti-CACNLB1 antibody |
Information sourced from Uniprot.org