Western blot analysis of 1) Mouse Brain Tissue, 2) Human Brain Tissue, with CaVα2δ3 Rabbit pAb diluted at 1:2,000.

Anti-CACNA2D3 antibody (500-580 aa) (STJ197410)

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STJ197410
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Short Description :Rabbit polyclonal anti-Voltage-dependent calcium channel subunit alpha-2/delta-3 (500-580 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Rabbit
Reactivity:Human/Rat/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range:WB 1:1000-2000
Formulation:Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:CACNA2D3
Gene ID:55799
Uniprot ID:CA2D3_HUMAN
Immunogen:Synthetic peptide derived from CaV Alpha 2 Delta 3 at the amino acid range 500-580
Immunogen Region:500-580 aa
Specificity:CaV Alpha 2 Delta 3 protein (A210) detects endogenous levels of CaV Alpha 2 Delta 3
Post Translational Modifications N-glycosylated. May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).
Protein Name Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3
Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3
Database Links Reactome: R-HSA-112308
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3 antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3 antibody
Anti-CACNA2D3 antibody

Information sourced from Uniprot.org

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