Anti-CACNA2D3 antibody (500-580 aa) (STJ197410)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide derived from CaV Alpha 2 Delta 3 at the amino acid range 500-580
General Information
| Short Description | Rabbit polyclonal anti-Voltage-dependent calcium channel subunit alpha-2/delta-3 (500-580 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA2D3 |
| Gene ID | 55799 |
| Uniprot ID | CA2D3_HUMAN |
| Immunogen | Synthetic peptide derived from CaV Alpha 2 Delta 3 at the amino acid range 500-580 |
| Immunogen Region | 500-580 aa |
| Specificity | CaV Alpha 2 Delta 3 protein (A210) detects endogenous levels of CaV Alpha 2 Delta 3 |
Additional Info
| Post Translational Modifications | N-glycosylated. May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3 |
| Database Links | Reactome: R-HSA-112308 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3 antibodyAnti-CACNA2D3 antibody |
Information sourced from Uniprot.org