Anti-CACNA1E antibody (370-450 aa) (STJ191632)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 370-450
General Information
| Short Description | Rabbit polyclonal anti-Voltage-dependent R-type calcium channel subunit alpha-1E (370-450 aa) for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA1E |
| Gene ID | 777 |
| Uniprot ID | CAC1E_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 370-450 |
| Immunogen Region | 370-450 aa |
| Specificity | CAC1E Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Isoform 3: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. |
| Protein Name | Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1eBrain Calcium Channel IiBiiCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 6Voltage-Gated Calcium Channel Subunit Alpha Cav2.3 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-422356 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1e antibodyAnti-Brain Calcium Channel Ii antibodyAnti-Bii antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 6 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav2.3 antibodyAnti-CACNA1E antibodyAnti-CACH6 antibodyAnti-CACNL1A6 antibody |
Information sourced from Uniprot.org