Anti-CACNA1B antibody (990-1040 aa) (STJ13100950)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 990-1040 of mouse CACNA1B conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-CACNA1B (990-1040 aa) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Cacna1b |
| Gene ID | 12287 |
| Uniprot ID | CAC1B_MOUSE |
| Immunogen | A synthetic peptide from aa region 990-1040 of mouse CACNA1B conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 990-1040 aa |
| Specificity | Specific for CACNA1B. |
Additional Info
| Post Translational Modifications | Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. |
| Protein Name | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1bBrain Calcium Channel IiiBiiiCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 |
| Database Links | Reactome: R-MMU-112308 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b antibodyAnti-Brain Calcium Channel Iii antibodyAnti-Biii antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 5 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 antibodyAnti-Cacna1b antibodyAnti-Cach5 antibodyAnti-Cacnl1a5 antibodyAnti-Cchn1a antibody |
Information sourced from Uniprot.org