| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Carbonic anhydrase 2 (161-260) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S8MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CA2 |
| Gene ID: |
760 |
| Uniprot ID: |
CAH2_HUMAN |
| Immunogen Region: |
161-260 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 161-260 of human Carbonic Anhydrase 2 (CA2) (P00918). |
| Immunogen Sequence: |
DVLDSIKTKGKSADFTNFDP RGLLPESLDYWTYPGSLTTP PLLECVTWIVLKEPISVSSE QVLKFRKLNFNGEGEPEELM VDNWRPAQPLKNRQIKASFK |
| Function | Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. |
| Protein Name | Carbonic Anhydrase 2Carbonate Dehydratase IiCarbonic Anhydrase CCacCarbonic Anhydrase IiCa-IiCyanamide Hydratase Ca2 |
| Database Links | Reactome: R-HSA-1237044Reactome: R-HSA-1247673Reactome: R-HSA-1475029 |
| Cellular Localisation | CytoplasmCell MembraneColocalized With Slc26a6 At The Surface Of The Cell Membrane In Order To Form A Bicarbonate Transport MetabolonDisplaced From The Cytosolic Surface Of The Cell Membrane By Pkc In Phorbol Myristate Acetate (Pma)-Induced Cells |
| Alternative Antibody Names | Anti-Carbonic Anhydrase 2 antibodyAnti-Carbonate Dehydratase Ii antibodyAnti-Carbonic Anhydrase C antibodyAnti-Cac antibodyAnti-Carbonic Anhydrase Ii antibodyAnti-Ca-Ii antibodyAnti-Cyanamide Hydratase Ca2 antibodyAnti-CA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Carbonic Anhydrase 2 (CA2) knockout (KO) 293T cells, using [KO Validated] Carbonic Anhydrase 2 (CA2) Rabbit polyclonal antibody (STJ11100007) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89080/357539/STJ11100007_1__88856.1713121655.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Carbonic Anhydrase 2 (CA2) knockout (KO) 293T cells, using [KO Validated] Carbonic Anhydrase 2 (CA2) Rabbit polyclonal antibody (STJ11100007) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")