| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S8MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CA2 |
| Gene ID: | 760 |
| Uniprot ID: | CAH2_HUMAN |
| Immunogen Region: | 161-260 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 161-260 of human Carbonic Anhydrase 2 (CA2) (P00918). |
| Immunogen Sequence: | DVLDSIKTKGKSADFTNFDP RGLLPESLDYWTYPGSLTTP PLLECVTWIVLKEPISVSSE QVLKFRKLNFNGEGEPEELM VDNWRPAQPLKNRQIKASFK |
| Function | Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. |
| Protein Name | Carbonic Anhydrase 2 Carbonate Dehydratase Ii Carbonic Anhydrase C Cac Carbonic Anhydrase Ii Ca-Ii Cyanamide Hydratase Ca2 |
| Database Links | Reactome: R-HSA-1237044 Reactome: R-HSA-1247673 Reactome: R-HSA-1475029 |
| Cellular Localisation | Cytoplasm Cell Membrane Colocalized With Slc26a6 At The Surface Of The Cell Membrane In Order To Form A Bicarbonate Transport Metabolon Displaced From The Cytosolic Surface Of The Cell Membrane By Pkc In Phorbol Myristate Acetate (Pma)-Induced Cells |
| Alternative Antibody Names | Anti-Carbonic Anhydrase 2 antibody Anti-Carbonate Dehydratase Ii antibody Anti-Carbonic Anhydrase C antibody Anti-Cac antibody Anti-Carbonic Anhydrase Ii antibody Anti-Ca-Ii antibody Anti-Cyanamide Hydratase Ca2 antibody Anti-CA2 antibody |
Information sourced from Uniprot.org