Anti-C4BPA antibody (C-Term) (STJ29962)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C4BPA (C-Term) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C4BPA |
| Gene ID | 722 |
| Uniprot ID | C4BPA_HUMAN |
| Immunogen Region | C-Term |
| Immunogen Sequence | QYVEPENVTIQCDSGYGVVG PQSITCSGNRTWYPEVPKCE WETPEGCEQVLTGKRLMQCL PNPEDVKMALEVYKLSLEIE QLELQRDSARQSTLDKEL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human C4BPA (NP_000706.1). |
Additional Info
| Tissue Specificity | Chylomicrons in the plasma. |
| Function | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It also interacts with anticoagulant protein S and with serum amyloid P component. |
| Protein Name | C4b-Binding Protein Alpha ChainC4bpProline-Rich ProteinPrp |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C4b-Binding Protein Alpha Chain antibodyAnti-C4bp antibodyAnti-Proline-Rich Protein antibodyAnti-Prp antibodyAnti-C4BPA antibodyAnti-C4BP antibody |
Information sourced from Uniprot.org