| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C4BPA |
| Gene ID: | 722 |
| Uniprot ID: | C4BPA_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human C4BPA (NP_000706.1). |
| Immunogen Sequence: | QYVEPENVTIQCDSGYGVVG PQSITCSGNRTWYPEVPKCE WETPEGCEQVLTGKRLMQCL PNPEDVKMALEVYKLSLEIE QLELQRDSARQSTLDKEL |
| Tissue Specificity | Chylomicrons in the plasma. |
| Function | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. |
| Protein Name | C4b-Binding Protein Alpha Chain C4bp Proline-Rich Protein Prp |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C4b-Binding Protein Alpha Chain antibody Anti-C4bp antibody Anti-Proline-Rich Protein antibody Anti-Prp antibody Anti-C4BPA antibody Anti-C4BP antibody |
Information sourced from Uniprot.org