Anti-C2 antibody (453-752) (STJ112224)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C2 (453-752) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C2 |
| Gene ID | 717 |
| Uniprot ID | CO2_HUMAN |
| Immunogen Region | 453-752 |
| Immunogen Sequence | LDVSKLTDTICGVGNMSANA SDQERTPWHVTIKPKSQETC RGALISDQWVLTAAHCFRDG NDHSLWRVNVGDPKSQWGKE FLIEKAVISPGFDVFAKKNQ GILEFYGDDIALLKLAQKVK MSTHARPICLPCTMEANLAL RRPQGSTCRDHENELLNKQS VPAHFVALNGSKLNINLKMG VEWTSCAEVVSQEKTMFPNL TDVREVVTDQFLCSGTQEDE SPCKGESGGAVFLERRFRF |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 453-752 of human C2 (NP_000054.2). |
Additional Info
| Post Translational Modifications | Cleaved and activated by different proteases depending on the complement pathway to generate complement C2a and serine protease complement C2b chains. Cleaved and activated by C1S following activation by the classical complement system. Cleaved and activated by MASP2 following activation by the lectin complement system. Cleaved and activated by GZMK following activation by the GZMK complement system. |
| Function | Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems. Serine protease complement C2b: Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex. |
| Protein Name | Complement C2C3/C5 Convertase Cleaved Into - Complement C2a - Serine Protease Complement C2b |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-174577Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedCell SurfaceRecruited To The Surface Of Pathogens By Complement C3b And Complement C4b Opsonins |
| Alternative Antibody Names | Anti-Complement C2 antibodyAnti-C3/C5 Convertase Cleaved Into - Complement C2a - Serine Protease Complement C2b antibodyAnti-C2 antibody |
Information sourced from Uniprot.org