• Western blot analysis of extracts of various cell lines, using C2 Antibody (STJ112224) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-C2 antibody (453-752) (STJ112224)

SKU:
STJ112224

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C2 (453-752) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: C2
Gene ID: 717
Uniprot ID: CO2_HUMAN
Immunogen Region: 453-752
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 453-752 of human C2 (NP_000054.2).
Immunogen Sequence: LDVSKLTDTICGVGNMSANA SDQERTPWHVTIKPKSQETC RGALISDQWVLTAAHCFRDG NDHSLWRVNVGDPKSQWGKE FLIEKAVISPGFDVFAKKNQ GILEFYGDDIALLKLAQKVK MSTHARPICLPCTMEANLAL RRPQGSTCRDHENELLNKQS VPAHFVALNGSKLNINLKMG VEWTSCAEVVSQEKTMFPNL TDVREVVTDQFLCSGTQEDE SPCKGESGGAVFLERRFRF
Function Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Protein Name Complement C2
C3/C5 Convertase Cleaved Into - Complement C2b Fragment - Complement C2a Fragment
Database Links Reactome: R-HSA-166663
Reactome: R-HSA-174577
Reactome: R-HSA-977606
Cellular Localisation Secreted
Alternative Antibody Names Anti-Complement C2 antibody
Anti-C3/C5 Convertase Cleaved Into - Complement C2b Fragment - Complement C2a Fragment antibody
Anti-C2 antibody

Information sourced from Uniprot.org

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