| Tissue Specificity | Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. |
| Function | Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. |
| Protein Name | Popeye Domain-Containing Protein 1Popeye Protein 1 |
| Database Links | |
| Cellular Localisation | Lateral Cell MembraneCell JunctionTight JunctionMembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaCaveolaColocalizes With Vamp3 At The Cell-Cell Contact In Cardiac And Skeletal MuscleIts Movement From The Cytoplasm To Membrane Is An Early Event Occurring Concurrently With Cell-Cell ContactColocalizes In Epithelial Cells With Ocln And Tjp1 In An Apical-Lateral Position Within The Z AxisDetected At Cell-Cell Contact But Never Observed At The Free Surface Of Epithelial Cells |
| Alternative Antibody Names | Anti-Popeye Domain-Containing Protein 1 antibodyAnti-Popeye Protein 1 antibodyAnti-POPDC1 antibodyAnti-BVES antibodyAnti-POP1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and GSTO1 knockout (KO) 293T cells, using [KO Validated] GSTO1 Rabbit polyclonal antibody (STJ11100768) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89705/358188/STJ11100768_1__90554.1713122502.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and GSTO1 knockout (KO) 293T cells, using [KO Validated] GSTO1 Rabbit polyclonal antibody (STJ11100768) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")
