| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BVES (241-360) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BVES |
| Gene ID: |
11149 |
| Uniprot ID: |
POPD1_HUMAN |
| Immunogen Region: |
241-360 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 241-360 of human BVES (NP_001186492.1). |
| Immunogen Sequence: |
SEPFLYEIFRYLIGKDITNK LYSLNDPTLNDKKAKKLEHQ LSLCTQISMLEMRNSIASSS DSDDGLHQFLRGTSSMSSLH VSSPHQRASAKMKPIEEGAE DDDDVFEPASPNTLKVHQLP |
| Tissue Specificity | Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. |
| Function | Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. |
| Protein Name | Blood Vessel Epicardial SubstanceHbvesPopeye Domain-Containing Protein 1Popeye Protein 1 |
| Cellular Localisation | Lateral Cell MembraneCell JunctionTight JunctionMembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaCaveolaColocalizes With Vamp3 At The Cell-Cell Contact In Cardiac And Skeletal MuscleIts Movement From The Cytoplasm To Membrane Is An Early Event Occurring Concurrently With Cell-Cell ContactColocalizes In Epithelial Cells With Ocln And Tjp1 In An Apical-Lateral Position Within The Z AxisDetected At Cell-Cell Contact But Never Observed At The Free Surface Of Epithelial Cells |
| Alternative Antibody Names | Anti-Blood Vessel Epicardial Substance antibodyAnti-Hbves antibodyAnti-Popeye Domain-Containing Protein 1 antibodyAnti-Popeye Protein 1 antibodyAnti-BVES antibodyAnti-POP1 antibodyAnti-POPDC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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