Anti-BVES antibody (241-360) (STJ22848)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BVES (241-360) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POPDC1 |
| Gene ID | 11149 |
| Uniprot ID | POPD1_HUMAN |
| Immunogen Region | 241-360 |
| Immunogen Sequence | SEPFLYEIFRYLIGKDITNK LYSLNDPTLNDKKAKKLEHQ LSLCTQISMLEMRNSIASSS DSDDGLHQFLRGTSSMSSLH VSSPHQRASAKMKPIEEGAE DDDDVFEPASPNTLKVHQLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 241-360 of human BVES (NP_001186492.1). |
Additional Info
| Tissue Specificity | Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. |
| Function | Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. |
| Protein Name | Popeye Domain-Containing Protein 1Popeye Protein 1 |
| Database Links | |
| Cellular Localisation | Lateral Cell MembraneCell JunctionTight JunctionMembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaCaveolaColocalizes With Vamp3 At The Cell-Cell Contact In Cardiac And Skeletal MuscleIts Movement From The Cytoplasm To Membrane Is An Early Event Occurring Concurrently With Cell-Cell ContactColocalizes In Epithelial Cells With Ocln And Tjp1 In An Apical-Lateral Position Within The Z AxisDetected At Cell-Cell Contact But Never Observed At The Free Surface Of Epithelial Cells |
| Alternative Antibody Names | Anti-Popeye Domain-Containing Protein 1 antibodyAnti-Popeye Protein 1 antibodyAnti-POPDC1 antibodyAnti-BVES antibodyAnti-POP1 antibody |
Information sourced from Uniprot.org