| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-BRCA1-associated protein is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 1E7-C9-D10-B10 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BRAP |
| Gene ID: | 8315 |
| Uniprot ID: | BRAP_HUMAN |
| Specificity: | This antibody detects endogenous levels of BRAP and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human BRAP protein fragments expressed in E.coli. |
| Function | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. |
| Protein Name | Brca1-Associated ProteinBrap2Impedes Mitogenic Signal PropagationImpRing Finger Protein 52Ring-Type E3 Ubiquitin Transferase Brap2Renal Carcinoma Antigen Ny-Ren-63 |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802955Reactome: R-HSA-9649948 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Brca1-Associated Protein antibodyAnti-Brap2 antibodyAnti-Impedes Mitogenic Signal Propagation antibodyAnti-Imp antibodyAnti-Ring Finger Protein 52 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Brap2 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-63 antibodyAnti-BRAP antibodyAnti-RNF52 antibody |
Information sourced from Uniprot.org
![Anti-IgG3 antibody [B10] (STJA0022535)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/191251/412695/STJA0022535-SDS-PAGE-1__65081.1749230150.jpg?c=1 "Anti-IgG3 antibody [B10] (STJA0022535)")
