| Post Translational Modifications | Phosphorylation at Ser-348 by SGK1 inhibits its activity. Dephosphorylation of Ser-348 by the SHOC2-MRAS-PP1c (SMP) complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (PPP1CA, PPP1CB or PPP1CC).this relieves inactivation and stimulates kinase activity. Methylation by PRMT5 decreases stability and kinase activity. Ubiquitinated by RNF149.which leads to proteasomal degradation. Polyubiquitinated at Lys-615 in response to EGF. |
| Function | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2. May play a role in the postsynaptic responses of hippocampal neurons. |
| Protein Name | Serine/Threonine-Protein Kinase B-RafProto-Oncogene B-Raf |
| Database Links | Reactome: R-MMU-1295596Reactome: -MMU-170968Reactome: -MMU-5673000Reactome: -MMU-5674135Reactome: -MMU-5674499Reactome: -MMU-5675221 |
| Cellular Localisation | NucleusCytoplasmCell MembraneColocalizes With Rgs14 And Raf1 In Both The Cytoplasm And Membranes |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase B-Raf antibodyAnti-Proto-Oncogene B-Raf antibodyAnti-Braf antibodyAnti-B-raf antibody |
Information sourced from Uniprot.org
