• STJ72783 (2µg/ml) staining of secretions from Human primary airway cells in culture (lanes 1 and 2) , and in Human Bronchoalveolar Lavage fluid (lanes 3 and 4). Data obtained from Dr. C Bingle, AURM, University of Sheffield, UK. Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-BPIFA1/PLUNC antibody (C-Term) (STJ72783)

SKU:
STJ72783-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-BPIFA1/PLUNC (C-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: BPIFA1
Gene ID: 51297
Uniprot ID: BPIA1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_057667.1
Specificity: Reported variants represent identical protein: NP_057667.1, NP_001230122.1, NP_570913.1
Immunogen Sequence: NEVLRGLDITLVHD
Post Translational Modifications May be N-glycosylated.
Function Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
Protein Name Bpi Fold-Containing Family A Member 1
Lung-Specific Protein X
Nasopharyngeal Carcinoma-Related Protein
Palate Lung And Nasal Epithelium Clone Protein
Secretory Protein In Upper Respiratory Tracts
Short Plunc1
Splunc1
Tracheal Epithelium-Enriched Protein
Von Ebner Protein Hl
Database Links Reactome: R-HSA-6803157
Cellular Localisation Secreted
Apical Side Of Airway Epithelial Cells
Detected In Airway Surface Liquid
Nasal Mucus And Sputum
Alternative Antibody Names Anti-Bpi Fold-Containing Family A Member 1 antibody
Anti-Lung-Specific Protein X antibody
Anti-Nasopharyngeal Carcinoma-Related Protein antibody
Anti-Palate Lung And Nasal Epithelium Clone Protein antibody
Anti-Secretory Protein In Upper Respiratory Tracts antibody
Anti-Short Plunc1 antibody
Anti-Splunc1 antibody
Anti-Tracheal Epithelium-Enriched Protein antibody
Anti-Von Ebner Protein Hl antibody
Anti-BPIFA1 antibody
Anti-LUNX antibody
Anti-NASG antibody
Anti-PLUNC antibody
Anti-SPLUNC1 antibody
Anti-SPURT antibody
Anti-UNQ787 antibody
Anti-PRO1606 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance