| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BMP1 (725-986) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BMP1 |
| Gene ID: |
649 |
| Uniprot ID: |
BMP1_HUMAN |
| Immunogen Region: |
725-986 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 725-986 of human BMP1 (NP_006120.1). |
| Immunogen Sequence: |
YECQCRSGFVLHDNKHDCKE AGCDHKVTSTSGTITSPNWP DKYPSKKECTWAISSTPGHR VKLTFMEMDIESQPECAYDH LEVFDGRDAKAPVLGRFCGS KKPEPVLATGSRMFLRFYSD NSVQRKGFQASHATECGGQV RADVKTKDLYSHAQFGDNNY PGGVDCEWVIVAEEGYGVEL VFQTFEVEEETDCGYDYMEL FDGYDSTAPRLGRYCGSGPP EEVYSAGDSVLVKFHSDDT |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. |
| Function | Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7. |
| Protein Name | Bone Morphogenetic Protein 1Bmp-1Mammalian Tolloid ProteinMtldProcollagen C-ProteinasePcp |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1650814Reactome: R-HSA-2214320Reactome: R-HSA-2243919Reactome: R-HSA-8963896 P13497-3 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkSecretedExtracellular SpaceExtracellular MatrixCo-Localizes With Postn In The GolgiIsoform Bmp1-3: Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 1 antibodyAnti-Bmp-1 antibodyAnti-Mammalian Tolloid Protein antibodyAnti-Mtld antibodyAnti-Procollagen C-Proteinase antibodyAnti-Pcp antibodyAnti-BMP1 antibodyAnti-PCOLC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
