Anti-BLOC1S1 antibody (29-153) (STJ28992)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BLOC1S1 (29-153) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BLOC1S1 |
| Gene ID | 2647 |
| Uniprot ID | BL1S1_HUMAN |
| Immunogen Region | 29-153 |
| Immunogen Sequence | MLSRLLKEHQAKQNERKELQ EKRRREAITAATCLTEALVD HLNVGVAQAYMNQRKLDHEV KTLQVQAAQFAKQTGQWIGM VENFNQALKEIGDVENWARS IELDMRTIATALEYVYKGQL QSAPS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 29-153 of human BLOC1S1 (NP_001478.2). |
Additional Info
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Acts as a protein acetyltransferase. Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 1Bloc-1 Subunit 1Gcn5-Like Protein 1Protein Rt14Protein Acetyltransferase Bloc1s1 |
| Database Links | Reactome: R-HSA-432720Reactome: R-HSA-432722 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixCytoplasmCytosolLysosome Membrane |
| Alternative Antibody Names | Anti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 1 antibodyAnti-Bloc-1 Subunit 1 antibodyAnti-Gcn5-Like Protein 1 antibodyAnti-Protein Rt14 antibodyAnti-Protein Acetyltransferase Bloc1s1 antibodyAnti-BLOC1S1 antibodyAnti-BLOS1 antibodyAnti-GCN5L1 antibodyAnti-RT14 antibody |
Information sourced from Uniprot.org