Anti-BDH2 antibody (STJA0004728)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFull length fusion protein
General Information
| Short Description | Rabbit polyclonal anti-Dehydrogenase/Reductase Sdr Family Member 6 for use in WB, IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | WB 1:500-1:2000, IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | BDH2 |
| Gene ID | 56898 |
| Uniprot ID | DHRS6_HUMAN |
| Immunogen | Full length fusion protein |
Additional Info
| Tissue Specificity | Detected in liver (at protein level). |
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 6(R-Beta-Hydroxybutyrate Dehydrogenase3-Hydroxybutyrate Dehydrogenase Type 24-Oxo-L-Proline ReductaseOxidoreductase UcpaShort Chain Dehydrogenase/Reductase Family 15c Member 1 |
| Database Links | Reactome: R-HSA-77111 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 6 antibodyAnti-(R-Beta-Hydroxybutyrate Dehydrogenase antibodyAnti-3-Hydroxybutyrate Dehydrogenase Type 2 antibodyAnti-4-Oxo-L-Proline Reductase antibodyAnti-Oxidoreductase Ucpa antibodyAnti-Short Chain Dehydrogenase/Reductase Family 15c Member 1 antibodyAnti-BDH2 antibodyAnti-DHRS6 antibodyAnti-SDR15C1 antibodyAnti-UNQ6308 antibodyAnti-PRO20933 antibody |
Information sourced from Uniprot.org