| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dehydrogenase/Reductase Sdr Family Member 6 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: |
Antigen affinity purification |
| Concentration: |
0.6 mg/mL |
| Dilution Range: |
WB 1:500-1:2000, IHC 1:50-1:300 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Tissue Specificity | Detected in liver (at protein level). |
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 6(R-Beta-Hydroxybutyrate Dehydrogenase3-Hydroxybutyrate Dehydrogenase Type 24-Oxo-L-Proline ReductaseOxidoreductase UcpaShort Chain Dehydrogenase/Reductase Family 15c Member 1 |
| Database Links | Reactome: R-HSA-77111 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 6 antibodyAnti-(R-Beta-Hydroxybutyrate Dehydrogenase antibodyAnti-3-Hydroxybutyrate Dehydrogenase Type 2 antibodyAnti-4-Oxo-L-Proline Reductase antibodyAnti-Oxidoreductase Ucpa antibodyAnti-Short Chain Dehydrogenase/Reductase Family 15c Member 1 antibodyAnti-BDH2 antibodyAnti-DHRS6 antibodyAnti-SDR15C1 antibodyAnti-UNQ6308 antibodyAnti-PRO20933 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
