Anti-BCDIN3D antibody (1-292) (STJ119854)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BCDIN3D (1-292) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BCDIN3D |
| Gene ID | 144233 |
| Uniprot ID | BN3D2_HUMAN |
| Immunogen Region | 1-292 |
| Immunogen Sequence | MAVPTELDGGSVKETAAEEE SRVLAPGAAPFGNFPHYSRF HPPEQRLRLLPPELLRQLFP ESPENGPILGLDVGCNSGDL SVALYKHFLSLPDGETCSDA SREFRLLCCDIDPVLVKRAE KECPFPDALTFITLDFMNQR TRKVLLSSFLSQFGRSVFDI GFCMSITMWIHLNHGDHGLW EFLAHLSSLCHYLLVEPQPW KCYRAAARRLRKLGLHDFDH FHSLAIRGDMPNQIVQILT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human BCDIN3D (NP_859059.1). |
Additional Info
| Function | O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145.however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145. |
| Protein Name | Rna 5'-Monophosphate MethyltransferaseBcdin3 Domain-Containing Protein |
| Database Links | Reactome: R-HSA-203927 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Rna 5'-Monophosphate Methyltransferase antibodyAnti-Bcdin3 Domain-Containing Protein antibodyAnti-BCDIN3D antibody |
Information sourced from Uniprot.org