| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BCDIN3D (1-292) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCDIN3D |
| Gene ID: |
144233 |
| Uniprot ID: |
BN3D2_HUMAN |
| Immunogen Region: |
1-292 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human BCDIN3D (NP_859059.1). |
| Immunogen Sequence: |
MAVPTELDGGSVKETAAEEE SRVLAPGAAPFGNFPHYSRF HPPEQRLRLLPPELLRQLFP ESPENGPILGLDVGCNSGDL SVALYKHFLSLPDGETCSDA SREFRLLCCDIDPVLVKRAE KECPFPDALTFITLDFMNQR TRKVLLSSFLSQFGRSVFDI GFCMSITMWIHLNHGDHGLW EFLAHLSSLCHYLLVEPQPW KCYRAAARRLRKLGLHDFDH FHSLAIRGDMPNQIVQILT |
| Function | O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145.however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145. |
| Protein Name | Rna 5'-Monophosphate MethyltransferaseBcdin3 Domain-Containing Protein |
| Database Links | Reactome: R-HSA-203927 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Rna 5'-Monophosphate Methyltransferase antibodyAnti-Bcdin3 Domain-Containing Protein antibodyAnti-BCDIN3D antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
