Anti-BCAP31/BAP31 antibody (C-Term) (STJ70154)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-BCAP31/BAP31 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 30kDa band observed in Human Placenta and Brain lysate (predicted MW of 28kDa according to NP_005736). Recommended for use at 1-3µg/ml.IHC: Paraffin embedded Human Kidney a |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | BCAP31 |
| Gene ID | 10134 |
| Uniprot ID | BAP31_HUMAN |
| Accession Number | NP_001132929.1; NP_005736.3 |
| Immunogen Region | C-Term |
| Immunogen Sequence | QAAVDGPMDKKEE |
| Specificity | This antibody is expected to recognise isoform a (NP_001132929.1) and isoform b (NP_005736.3; NP_001132913.1). |
Additional Info
| Post Translational Modifications | Cleaved by CASP8 and other caspases. |
| Function | Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40. In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2. May be involved in CASP8-mediated apoptosis. |
| Protein Name | B-Cell Receptor-Associated Protein 31Bcr-Associated Protein 31Bap316c6-Ag Tumor-Associated AntigenProtein CdmP28 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-75153Reactome: R-HSA-8980692Reactome: R-HSA-983170Reactome: R-HSA-9833110 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneMay Shuttle Between The Er And The Intermediate Compartment/Cis-Golgi ComplexAssociates With The Mitochondria-Associated Endoplasmic Reticulum Membrane Via Interaction With Tomm40(Microbial Infection) Upon Sv40 InfectionColocalizes With Dnajc18Dnajb12 And Dnajb14 In Punctate Structures Within The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-B-Cell Receptor-Associated Protein 31 antibodyAnti-Bcr-Associated Protein 31 antibodyAnti-Bap31 antibodyAnti-6c6-Ag Tumor-Associated Antigen antibodyAnti-Protein Cdm antibodyAnti-P28 antibodyAnti-BCAP31 antibodyAnti-BAP31 antibodyAnti-DXS1357E antibody |
Information sourced from Uniprot.org