Axin 2 antibody western blot K562 C6 3T3 HeLa STJA0034058

Anti-Axin 2 antibody [R06-3A8] (STJA0034058)

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STJA0034058
€160.20 - €337.80
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Short Description :Rabbit monoclonal anti-Axin 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :R06-3A8
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.3 mg/mL
Purification:Affinity Purified
Dilution Range:WB 1:500-1:1000
Formulation:50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:AXIN2
Gene ID:8313
Uniprot ID:AXIN2_HUMAN
Immunogen:A synthetic peptide of human Axin 2
Tissue Specificity Expressed in brain and lymphoblast.
Post Translational Modifications Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
Function Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Protein Name Axin-2
Axin-Like Protein
Axil
Axis Inhibition Protein 2
Conductin
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4411364
Reactome: R-HSA-4641257
Reactome: R-HSA-5689880
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Axin-2 antibody
Anti-Axin-Like Protein antibody
Anti-Axil antibody
Anti-Axis Inhibition Protein 2 antibody
Anti-Conductin antibody
Anti-AXIN2 antibody

Information sourced from Uniprot.org

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