Anti-Axin 2 antibody [R06-3A8] (STJA0034058)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Axin 2
General Information
| Short Description | Rabbit monoclonal anti-Axin 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-3A8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | AXIN2 |
| Gene ID | 8313 |
| Uniprot ID | AXIN2_HUMAN |
| Immunogen | A synthetic peptide of human Axin 2 |
Additional Info
| Tissue Specificity | Expressed in brain and lymphoblast. |
| Post Translational Modifications | Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. |
| Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Protein Name | Axin-2Axin-Like ProteinAxilAxis Inhibition Protein 2Conductin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4411364Reactome: R-HSA-4641257Reactome: R-HSA-5689880 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Axin-2 antibodyAnti-Axin-Like Protein antibodyAnti-Axil antibodyAnti-Axis Inhibition Protein 2 antibodyAnti-Conductin antibodyAnti-AXIN2 antibody |
Information sourced from Uniprot.org