Anti-ATXN2 antibody (1250-1331) (STJ119084)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ATXN2 (1250-1331) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATXN2 |
| Gene ID | 6311 |
| Uniprot ID | ATX2_HUMAN |
| Immunogen Region | 1250-1331 |
| Immunogen Sequence | HVQSGMVPSHPTAHAPMMLM TTQPPGGPQAALAQSALQPI PVSTTAHFPYMTHPSVQAHH QQQL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1250-1331 of human ATXN2 (NP_002964.3). |
Additional Info
| Tissue Specificity | Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. |
| Function | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. |
| Protein Name | Ataxin-2Spinocerebellar Ataxia Type 2 ProteinTrinucleotide Repeat-Containing Gene 13 Protein |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ataxin-2 antibodyAnti-Spinocerebellar Ataxia Type 2 Protein antibodyAnti-Trinucleotide Repeat-Containing Gene 13 Protein antibodyAnti-ATXN2 antibodyAnti-ATX2 antibodyAnti-SCA2 antibodyAnti-TNRC13 antibody |
Information sourced from Uniprot.org