| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP6V1B2 (262-511) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATP6V1B2 |
| Gene ID: |
526 |
| Uniprot ID: |
VATB2_HUMAN |
| Immunogen Region: |
262-511 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 262-511 of human ATP6V1B2 (NP_001684.2). |
| Immunogen Sequence: |
NLANDPTIERIITPRLALTT AEFLAYQCEKHVLVILTDMS SYAEALREVSAAREEVPGRR GFPGYMYTDLATIYERAGRV EGRNGSITQIPILTMPNDDI THPIPDLTGYITEGQIYVDR QLHNRQIYPPINVLPSLSRL MKSAIGEGMTRKDHADVSNQ LYACYAIGKDVQAMKAVVGE EALTSDDLLYLEFLQKFERN FIAQGPYENRTVFETLDIGW QLLRIFPKEMLKRIPQSTL |
| Tissue Specificity | Kidney.localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). |
| Function | Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load. |
| Protein Name | V-Type Proton Atpase Subunit B - Brain IsoformV-Atpase Subunit B 2Endomembrane Proton Pump 58 Kda SubunitHo57Vacuolar Proton Pump Subunit B 2 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712 |
| Cellular Localisation | Apical Cell MembraneMelanosomeCytoplasmCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembranePeripheral Membrane ProteinClathrin-Coated Vesicle MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-V-Type Proton Atpase Subunit B - Brain Isoform antibodyAnti-V-Atpase Subunit B 2 antibodyAnti-Endomembrane Proton Pump 58 Kda Subunit antibodyAnti-Ho57 antibodyAnti-Vacuolar Proton Pump Subunit B 2 antibodyAnti-ATP6V1B2 antibodyAnti-ATP6B2 antibodyAnti-VPP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
